A method and system of providing content-aware persistent advertisements comprises the steps of ingesting and collecting VDNA (Video DNA) fingerprints of media contents playing on various network-enabled terminals including Internet browsers, mobile devices, tablets, smart televisions and so on; sending the ingested fingerprints along with other information such as metadata, user's location, etc, to the content identification server via Internet or mobile networks, and selecting accurate advertisements according to the media content and relevant information, then finally pushing the advertisements back to user's terminal. With VDNA fingerprint identification, media contents are identified by content instead of metadata or other surrounding information, so that the result of identification can be considered genuine, and the chosen advertisements based on the media content can be persistent across multiple terminals playing the same media content.