A signal conditioning system for a distributed antenna network includes a donor antenna in a first location receiving a downlink radio frequency signal from a radio frequency source. A service antenna is in a second location different from the first location, wherein the service antenna transmits the downlink radio frequency signal to an end user device, and the end user device transmits an uplink radio frequency signal back to the service antenna. Separate gain control amplifiers process the uplink and downlink signals and are located at the separate first and second locations to reduce thermal noise in the uplink and downlink signals. Reduced thermal noise allows quality transmission over optical fibers in addition to coaxial cables. First and second microcontrollers at the first and second locations control respective attenuators and transmit power level data to remote computer processors.