Invention Grant
US09409953B2 Viral vectors with modified transduction profiles and methods of making and using the same
有权
具有修饰的转导概况的病毒载体及其制备和使用方法
- Patent Title: Viral vectors with modified transduction profiles and methods of making and using the same
- Patent Title (中): 具有修饰的转导概况的病毒载体及其制备和使用方法
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Application No.: US13984840Application Date: 2012-02-10
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Publication No.: US09409953B2Publication Date: 2016-08-09
- Inventor: Aravind Asokan , Nagesh Pulicherla
- Applicant: Aravind Asokan , Nagesh Pulicherla
- Applicant Address: US NC Chapel Hill
- Assignee: The University of North Carolina at Chapel Hill
- Current Assignee: The University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Myers Bigel & Sibley, P.A.
- International Application: PCT/US2012/024702 WO 20120210
- International Announcement: WO2012/109570 WO 20120816
- Main IPC: C07K14/005
- IPC: C07K14/005 ; C12N15/86 ; C12N7/00 ; C07K14/015 ; C07K14/01 ; A61K39/23 ; C12N15/35
Abstract:
The present invention provides AAV capsid proteins, virus capsids comprising said capsid proteins and virus vectors comprising said capsid proteins, wherein the AAV capsid proteins have one or more mutations, wherein the mutation(s) result in a phenotype of decreased liver transduction and/or reduced glycan binding affinity as compared to a control. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject.
Public/Granted literature
- US20140056854A1 VIRAL VECTORS WITH MODIFIED TRANSDUCTION PROFILES AND METHODS OF MAKING AND USING THE SAME Public/Granted day:2014-02-27
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