Invention Grant
- Patent Title: Growth hormone releasing peptides
- Patent Title (中): 生长激素释放肽
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Application No.: US14510188Application Date: 2014-10-09
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Publication No.: US09409948B2Publication Date: 2016-08-09
- Inventor: Zheng Xin Dong
- Applicant: Ipsen Pharma S.A.S.
- Applicant Address: FR Boulogne-Billancourt
- Assignee: Ipsen Pharma S.A.S.
- Current Assignee: Ipsen Pharma S.A.S.
- Current Assignee Address: FR Boulogne-Billancourt
- Agent Eileen J. Ennis; Janice M. Klunder
- Main IPC: C07K7/06
- IPC: C07K7/06 ; C07K5/02 ; C07K5/062 ; C07K5/107 ; C07K5/117 ; C07K7/02 ; C07K14/60 ; A61K38/00
Abstract:
Disclosed are peptide and peptidomimetic compounds generally according to formula (I) that are useful as GHRP analogs: R1-A1-A2-A3-A4-A5-R2 (I) wherein: A1 is Aib, Apc or Inp; A2 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A3 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A4 is 2Fua, Orn, 2Pal, 3Pal, 4Pal, Pff, Phe, Pim, Taz, 2Thi, 3Thi, Thr(Bzl); A5 is Apc, Dab, Dap, Lys, Orn, or deleted; R1 is hydrogen, (C1-6)alkyl, (C5-14)aryl, (C1-6)alkyl(C5-14)aryl, (C3-8)cycloakyl, or (C2-10)acyl; and R2 is OH or NH2; and pharmaceutical compositions and methods of use thereof.
Public/Granted literature
- US20150031615A1 Growth Hormone Releasing Peptides Public/Granted day:2015-01-29
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