Invention Grant
- Patent Title: Single step polymerization of covalently bound multilayer matrices
- Patent Title (中): 共价结合的多层基质的单步聚合
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Application No.: US13794546Application Date: 2013-03-11
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Publication No.: US09409322B2Publication Date: 2016-08-09
- Inventor: Adah Almutairi , Yogesh Ner , Jerome Karpiak , Jose Morachis
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee Address: US CA Oakland
- Agency: Musick Davis LLP
- Agent Eleanor Musick
- Main IPC: B29C39/12
- IPC: B29C39/12 ; A61L27/52 ; A61L27/16 ; A61L27/18 ; A61L27/26 ; A61L27/38 ; A61L27/50 ; A61L27/54 ; A61L27/56 ; B29C67/00
Abstract:
A method is provided for forming complex tissue using density gradient multilayer polymerization (DGMP) to form strong hydrogels with smooth transitions between layers. The multicompartment hydrogel is formed by co-dissolving a polymer precurser with a constituent in multiple solvent fractions to a create prepolymer solutions with different densities, layering the prepolymer solutions on top of each other from high to low solvent density, and irradiating the prepolymer solutions to form a polymer. The hydrogels may be used as biomimetic matrices.
Public/Granted literature
- US20130234372A1 SINGLE STEP POLYMERIZATION OF COVALENTLY BOUND MULTILAYER MATRICES Public/Granted day:2013-09-12
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