A chambered bottle for separately storing wet and dry ingredients for subsequent mixing is provided. The chambered bottle may include a wet chamber, a dry chamber, a dome-shaped regulator and a drinking spout. The wet chamber and the dry chamber are interconnected by the regulator so as to be positionable in a closed configuration, for storing separated wet and dry contents, and an opened configuration whereby the wet and dry contents are mixable. The regulator provides a protrusion and a similarly shaped aperture. The wet chamber engages the regulator with a similarly dimensioned domed diaphragm providing a depression and a similarly shaped aperture. When the diaphragm and regulator apertures align, then the wet and dry contents of the wet and dry chambers, respectively, are mixed into a desired solution in the opened configuration.