Disclosed are systems, methods and computer program products for encryption of disk based on pre-boot compatibility testing. An example method includes upon determining, by a processor, no test booting of the computer, performing one or more pre-boot compatibility tests to boot an operating system of the computer; upon detecting a successful test booting, performing booting the operating system of the computer or performing the one or more pre-boot compatibility tests again; upon detecting an unsuccessful test booting, restoring a process of ordinary booting of the operating system and performing an ordinary booting of the operating system; determining one or more encryption policies applicable to a pre-boot execution stage of the computer; and comparing results of the one or more pre-boot compatibility tests with the encryption policies to determine whether to apply a full disk encryption to the boot disk.