Invention Grant
- Patent Title: Human optimized Bacillus anthracis protective antigen
-
Application No.: US14190464Application Date: 2014-02-26
-
Publication No.: US09382547B2Publication Date: 2016-07-05
- Inventor: Stanley Goldman , Mark Albrecht
- Applicant: Stanley Goldman , Mark Albrecht
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Navy
- Current Assignee: The United States of America as represented by the Secretary of the Navy
- Current Assignee Address: US DC Washington
- Agent Albert M. Churilla; Ning Yang; Diane P. Tso
- Main IPC: C12N15/64
- IPC: C12N15/64 ; A61K39/07 ; C07K14/32 ; A61K39/00
Abstract:
The invention relates to a humanized nucleic acid construct from Bacillus anthracis protective antigen (PA) gene and method of modifying the gene. The humanized gene, and method of producing it, improves the structural fidelity of expressed protein product, when produced in mammalian host cells, to native, bacterially produced protein. The construct is useful in nucleic acid based vaccine formulations against B. anthracis.
Public/Granted literature
- US20150240245A1 Human optimized Bacillus anthracis protective antigen Public/Granted day:2015-08-27
Information query
IPC分类:
