Invention Grant
US09382540B2 Compositions and methods for modulating angiopoietin-like 3 expression
有权
调节血管生成素样3表达的组合物和方法
- Patent Title: Compositions and methods for modulating angiopoietin-like 3 expression
- Patent Title (中): 调节血管生成素样3表达的组合物和方法
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Application No.: US14701999Application Date: 2015-05-01
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Publication No.: US09382540B2Publication Date: 2016-07-05
- Inventor: Thazha P. Prakash , Punit P. Seth , Eric E. Swayze , Susan M. Freier , Mark J. Graham , Rosanne M. Crooke
- Applicant: Isis Pharmaceuticals, Inc.
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc
- Current Assignee: Isis Pharmaceuticals, Inc
- Current Assignee Address: US CA Carlsbad
- Agency: Ionis Patent Department
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/113
Abstract:
Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing lipids and/or glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease and/or metabolic disease, or a symptom thereof, in an individual in need thereof.
Public/Granted literature
- US20150315594A1 COMPOSITIONS AND METHODS FOR MODULATING ANGIOPOIETIN-LIKE 3 EXPRESSION Public/Granted day:2015-11-05
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