Invention Grant
- Patent Title: Modulation of synaptic maintenance
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Application No.: US14751921Application Date: 2015-06-26
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Publication No.: US09382313B2Publication Date: 2016-07-05
- Inventor: Ben A. Barres , Beth A. Stevens
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Stanford
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Stanford
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K31/00 ; A61K31/727 ; A61K45/06 ; G01N33/50 ; G01N33/564 ; G01N33/68 ; A61K39/395 ; A61K48/00 ; A61K39/00
Abstract:
C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including Alzheimer's disease.
Public/Granted literature
- US20150368325A1 MODULATION OF SYNAPTIC MAINTENANCE Public/Granted day:2015-12-24
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