Invention Grant
- Patent Title: Relaxin fusion polypeptides and uses thereof
- Patent Title (中): 松弛蛋白融合多肽及其用途
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Application No.: US14130493Application Date: 2012-06-29
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Publication No.: US09382305B2Publication Date: 2016-07-05
- Inventor: Andreas Wilmen , Ulrich Haupts , Christoph Freiberg , Mark Trautwein , Lars Linden , Kirsten Leineweber , Hanna Tinel
- Applicant: Andreas Wilmen , Ulrich Haupts , Christoph Freiberg , Mark Trautwein , Lars Linden , Kirsten Leineweber , Hanna Tinel
- Applicant Address: DE Monheim
- Assignee: BAYER INTELLECTUAL PROPERTY GMBH
- Current Assignee: BAYER INTELLECTUAL PROPERTY GMBH
- Current Assignee Address: DE Monheim
- Agent Thomas C. Blankinship; Yonggang Ji
- Priority: EP11172413 20110701; EP11172681 20110705
- International Application: PCT/EP2012/062665 WO 20120629
- International Announcement: WO2013/004607 WO 20130110
- Main IPC: C07K14/64
- IPC: C07K14/64 ; C07K19/00 ; A61K38/22 ; C12N15/16 ; C07K16/18 ; A61K38/00
Abstract:
The present invention provides Relaxin fusion polypeptides A-L-B with a non-wild type array of the Relaxin A-chain and Relaxin B-chain, wherein the A- and B-chains are connected by a linker peptide. The invention further provides Relaxin fusion polypeptides with extended half-life. Furthermore, the invention provides nucleic acid sequences encoding the foregoing fusion polypeptides, vectors containing the same, pharmaceutical compositions and medical use of such fusion polypeptides.
Public/Granted literature
- US20140187491A1 RELAXIN FUSION POLYPEPTIDES AND USES THEREOF Public/Granted day:2014-07-03
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