Invention Grant
- Patent Title: Oxazolidone compound, preparing method and application thereof
- Patent Title (中): 恶唑烷酮化合物，其制备方法和应用
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Application No.: US14761843Application Date: 2013-12-30
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Publication No.: US09382265B2Publication Date: 2016-07-05
- Inventor: Yushe Yang , Tao Xue , Shi Ding , Bin Guo
- Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES , ZHE JIANG JUTAI PHARMACEUTICAL CO., LTD.
- Applicant Address: CN Shanghai CN Quzhou
- Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Zhe Jiang Jutai Pharmaceutical Co., Ltd.
- Current Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Zhe Jiang Jutai Pharmaceutical Co., Ltd.
- Current Assignee Address: CN Shanghai CN Quzhou
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- Priority: CN201310020040 20130118
- International Application: PCT/CN2013/090833 WO 20131230
- International Announcement: WO2014/110971 WO 20140724
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D519/00
Abstract:
The present invention relates to the field of a pharmaceutical compound, and more specifically, relates to a new oxazolidone compound, an enantiomer, a diastereoisomer and a raceme thereof, and a mixture thereof, and a pharmaceutically acceptable salt thereof, a preparation method thereof, an application thereof as a bioactive substance in a drug. The compound in the present invention has strong anticoagulant activity, does not affect the activity of thrombin, and can reduce the risk of hemorrhage. A pharmacokinetics experiment shows that the compound in the present invention further has good metabolic characteristics, and has a far better oral bioavailability than a positive contrastive agent rivaroxaban.
Public/Granted literature
- US20150361091A1 OXAZOLIDONE COMPOUND, PREPARING METHOD AND APPLICATION THEREOF Public/Granted day:2015-12-17
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