Invention Grant
US09382235B2 Unsolvated crystalline form 1 of N-[5-(3, 5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide and methods of use thereof
有权
N- [5-（3,5-二氟 - 苄基）-1H-吲唑-3-基] -4-（4-甲基 - 哌嗪-1-基）-2-（四氢 - 吡喃-2-基） 吡啶-4-基氨基） - 苯甲酰胺及其使用方法
![Unsolvated crystalline form 1 of N-[5-(3, 5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide and methods of use thereof](/docs/US/2016-07-05/US09382235B2/abs.jpg.600x600.jpg)
- Patent Title: Unsolvated crystalline form 1 of N-[5-(3, 5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide and methods of use thereof
- Patent Title (中): N- [5-（3,5-二氟 - 苄基）-1H-吲唑-3-基] -4-（4-甲基 - 哌嗪-1-基）-2-（四氢 - 吡喃-2-基） 吡啶-4-基氨基） - 苯甲酰胺及其使用方法
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Application No.: US14716986Application Date: 2015-05-20
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Publication No.: US09382235B2Publication Date: 2016-07-05
- Inventor: Natale Alvaro Barbugian , Romualdo Forino , Tiziano Fumagalli , Paolo Orsini
- Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
- Applicant Address: IT Nerviano (MI)
- Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
- Current Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
- Current Assignee Address: IT Nerviano (MI)
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP12169139 20120523
- Main IPC: C07D405/12
- IPC: C07D405/12 ; A61K31/496 ; C07D405/14
![Unsolvated crystalline form 1 of N-[5-(3, 5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide and methods of use thereof](/abs-image/US/2016/07/05/US09382235B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H -indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
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