Invention Grant
US09381210B2 Induced pluripotent stem cell model of chronic myeloid leukemia revealed olfactomedin 4 as a novel therapeutic target in leukemia stem cells
有权
诱导的多能干细胞模型的慢性骨髓性白血病显示了嗅觉素4作为白血病干细胞的新型治疗靶点
- Patent Title: Induced pluripotent stem cell model of chronic myeloid leukemia revealed olfactomedin 4 as a novel therapeutic target in leukemia stem cells
- Patent Title (中): 诱导的多能干细胞模型的慢性骨髓性白血病显示了嗅觉素4作为白血病干细胞的新型治疗靶点
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Application No.: US14251231Application Date: 2014-04-11
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Publication No.: US09381210B2Publication Date: 2016-07-05
- Inventor: Igor I. Slukvin , Kran Suknuntha
- Applicant: Wisconsin Alumni Research Foundation
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Quarles & Brady LLP
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/02 ; C07H21/04 ; A61K31/713 ; A61K31/506 ; G01N33/50 ; C12N5/095 ; C12N5/0789 ; G01N33/574 ; A61K45/06 ; A61K31/496 ; A61K31/5025 ; A61K31/517 ; C12N5/00
Abstract:
Disclosed herein are compositions and methods to treat and reduce therapeutic resistance in chronic myelogenous leukemia. Also disclosed herein are methods to generate leukemia stem cell like cells (iLSCs) generated from CML patient-derived iPSCs, and methods for utilizing iLSCs in screens to identify modulators of CML drug resistance and gene targets that underlie CML drug resistance.
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