Systems and methods for suppressing transmitter noise in a receive band of a co-located receiver that are suitable for wideband applications are disclosed. In one embodiment, an analog radio frequency transmit signal output by a transmitter includes a desired signal in a transmit band of the transmitter and transmitter noise in a receive band of a main receiver. A secondary receiver obtains a secondary receiver input signal that is representative of at least the transmitter noise in the receive band of the main receiver and outputs a digital feedforward signal. A digital feedforward transmit noise cancellation subsystem generates a digital transmitter noise cancellation signal that is representative of the transmitter noise in the receive band based on the digital feedforward signal and subtracts the digital transmitter noise cancellation signal from a digital receive signal output by the main receiver to thereby provide a compensated digital receive signal.