An article anti-lost device comprises a plurality of sensors and a host. Each sensor comprises a recognition module and a sensor signal transceiver module. The host comprises a control module, a host signal transceiver module, a host warning module, an operation module and a display module. In an article anti-lost method, the host and the sensor are firstly paired, and then the sensor is combined with a to-be-monitored article and a warning distance is set. When a distance between the sensor and the host exceeds the warning distance, a warning signal is outputted, and an orientation and a distance of the sensor are prompted on the host. With the structure and the method, when the article leaves the user by a predetermined distance, the user can be reminded to prevent the article from getting lost or stolen.