A method, a control unit and a system for image reconstruction and visualization of a tomosynthesis volume. Different region of interests are detected in the volume and specific types of lesions are determined. Based on the type of lesion, different reconstruction parameters and different reconstruction algorithms are applied in order to reconstruct a sub-volume or a region in a projection. After displaying the digital breast tomosynthesis volume, a user selection signal is received, in order to identify a selection area. The selection area identifies a region in the volume which should be reconstructed differently from the remaining volume and typically with higher resolution, because it refers to a region of specific interest. After having received the user selection signal the selection area is defined and a pre-computed or online-computed reconstruction of the selection area is visualized. The reconstruction is executed according to the determined lesion type specific reconstruction parameters.