A micro-needle roller infusion system for transdermal or intradermal delivery of active agents, skin-care products, and other topical formulations is provided. The infusion system comprises a needle roller assembly with needles enclosed in a housing with a disposable cartridge having the active agent. The device offers the advantages of creating a path for the active agents to reach or be injected into the desired depth for an easier, more effective interaction with the target skin layer. Apart from the approximation of the agent to the target, the device also provides biological benefits of the needling therapy of collagen generation and skin rejuvenation coupled with superior convenience and ease of use.