A system for replacing a trochlear groove region of a femur. The system includes a prosthesis that includes a bone contact surface and a periphery that defines an outer perimeter. The bone contact surface has a plurality of protrusions and a spatial configuration with respect to one another. Additionally, the system includes a first template that has a plurality of guide holes and a first periphery that defines an outer perimeter that substantially corresponds with the periphery of the prosthesis. Also, included in the system is a second template that has a plurality of guide holes and a second periphery that defines an outer perimeter that substantially corresponds with the periphery of the prosthesis. The plurality of guide holes of the second template are spatially arranged with respect to the second periphery to substantially match the spatial configuration of the plurality of protrusions of the prosthesis.