Invention Grant
US09358096B2 Methods of treatment with drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations
有权
使用药物洗脱支架进行治疗的方法，具有局部高浓度和低全身浓度的局部洗脱曲线
- Patent Title: Methods of treatment with drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations
- Patent Title (中): 使用药物洗脱支架进行治疗的方法，具有局部高浓度和低全身浓度的局部洗脱曲线
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Application No.: US13908854Application Date: 2013-06-03
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Publication No.: US09358096B2Publication Date: 2016-06-07
- Inventor: Kent C. B. Stalker , Winnette S. McIntosh , Dudley S. Jayasinghe , Gregory C. Orr , John E. Papp , Lewis B. Schwartz
- Applicant: Abbott Laboratories
- Applicant Address: US IL Abbott Park
- Assignee: Abbott Laboratories
- Current Assignee: Abbott Laboratories
- Current Assignee Address: US IL Abbott Park
- Agency: Squire Patton Boggs (US) LLP
- Main IPC: A61F2/06
- IPC: A61F2/06 ; A61L31/02 ; A61L31/10 ; A61L31/16
Abstract:
A drug eluting stent can include a stent body having a polymeric coating with a lipophilic and/or hydrophilic element. A drug that has a bioactivity that inhibits cell proliferation can be disposed in the polymeric coating. The drug can be present in the polymer at an amount greater than or equal to about 150 μg/cm2. The polymeric coating and drug are configured to cooperate so as to form a diffusion pathway with tissue when the stent is disposed in a body lumen such that the drug preferentially diffuses into the tissue over a body fluid passing through the body lumen such that a maximum systemic blood concentration of the drug is less than about 40 ng/ml.
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