Methods and apparatus to avoid mobile station transmission of duplicate event-based and polled acknowledgments are disclosed. Example methods disclosed herein for a mobile station include determining whether an acknowledgment status of a first downlink data block classified as unreported is to be reported by a polled acknowledgment response to be sent in response to a poll received from a network, sending event-based acknowledgment information to report the acknowledgment status of the first downlink data block after determining that the acknowledgment status of the first downlink data block is not to be reported by the polled acknowledgment response, and refraining from sending the event-based acknowledgment information to report the acknowledgment status of the first downlink data block after determining that the acknowledgment status of the first downlink data block is to be reported by the polled acknowledgment response.