Display calibration systems and related methods are disclosed that use photo-sensitivity of LEDs to correct for variations between LEDs during initial production and over lifetime for display systems. The display devices include arrays of LEDs and use photo-sensitivity of the LEDs to correct for variations between LEDs. Such LED arrays can produce images directly as in LED billboards and sports arena scoreboards, and smaller Organic LED (OLED) displays, or can produce the backlight for LCD screens for instance. Variations in LED brightness and color can be compensated for in order for such a display to have uniform color and brightness. This compensation is performed in the embodiments disclosed by measuring the signal induced on each LED by uniform incident light as a measurement of the photo-sensitivity of the LEDs.