Invention Grant
US09273134B2 Inhibitors of receptor tyrosine kinases and methods of use thereof
有权
受体酪氨酸激酶的抑制剂及其使用方法
- Patent Title: Inhibitors of receptor tyrosine kinases and methods of use thereof
- Patent Title (中): 受体酪氨酸激酶的抑制剂及其使用方法
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Application No.: US12602235Application Date: 2008-06-05
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Publication No.: US09273134B2Publication Date: 2016-03-01
- Inventor: Joseph Schlessinger , Irit Lax , Satoru Yuzawa , Yarden Opatowsky , Yan Yang
- Applicant: Joseph Schlessinger , Irit Lax , Satoru Yuzawa , Yarden Opatowsky , Yan Yang
- Applicant Address: US CT New Haven
- Assignee: Yale University
- Current Assignee: Yale University
- Current Assignee Address: US CT New Haven
- Agency: McCarter & English, LLP
- Agent Maria Laccotripe Zacharakis; Marcie B. Clarke
- International Application: PCT/US2008/007104 WO 20080605
- International Announcement: WO2008/153926 WO 20081218
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/00
Abstract:
The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.
Public/Granted literature
- US20110311538A1 INHIBITORS OF RECEPTOR TYROSINE KINASES AND METHODS OF USE THEREOF Public/Granted day:2011-12-22
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