Invention Grant
- Patent Title: Stabilized alpha helical peptides and uses thereof
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Application No.: US13252751Application Date: 2011-10-04
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Publication No.: US09273099B2Publication Date: 2016-03-01
- Inventor: Loren D. Walensky , Stanley J. Korsmeyer , Gregory Verdine
- Applicant: Loren D. Walensky , Stanley J. Korsmeyer , Susan Korsmeyer , Gregory Verdine
- Applicant Address: US MA Cambridge US MA Boston
- Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE,DANA-FARBER CANCER INSTITUTE, INC.
- Current Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE,DANA-FARBER CANCER INSTITUTE, INC.
- Current Assignee Address: US MA Cambridge US MA Boston
- Agency: Wilson Sonsini Goodrich & Rosati
- Main IPC: C07K11/02
- IPC: C07K11/02 ; C07K7/64 ; C07K14/00 ; C07K14/47 ; C07K1/113 ; C07K14/435 ; A61K38/00
Abstract:
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.
Public/Granted literature
- US20120082636A1 STABILIZED ALPHA HELICAL PEPTIDES AND USES THEREOF Public/Granted day:2012-04-05
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