Invention Grant
US09273064B2 Benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors
有权
苯并二氧杂环戊烯或苯并二氧杂环杂环化合物作为磷酸二酯酶抑制剂
- Patent Title: Benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors
- Patent Title (中): 苯并二氧杂环戊烯或苯并二氧杂环杂环化合物作为磷酸二酯酶抑制剂
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Application No.: US14586681Application Date: 2014-12-30
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Publication No.: US09273064B2Publication Date: 2016-03-01
- Inventor: Simon Feldbaek Nielsen
- Applicant: LEO PHARMA A/S
- Applicant Address: DK Ballerup
- Assignee: LEO PHARMA A/S
- Current Assignee: LEO PHARMA A/S
- Current Assignee Address: DK Ballerup
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Main IPC: C07D495/10
- IPC: C07D495/10 ; C07D493/10 ; A61K31/4427 ; A61K31/4433

Abstract:
Compounds of the general formula I wherein each of m and n is independently 0 or 1; R1 and R2, together with the carbon atom to which they are attached, form a heterocyclic ring comprising one or two heteroatoms selected from oxygen, sulfur, —S(O)— and —S(O)2—; R3 is —CHF2, —CF3, —OCHF2, —OCF3, —SCHF2 or —SCF3; X is a bond, —CH2—, or —NH—; A is aryl, cycloalkyl, cycloalkenyl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkenyl, optionally substituted with one or more, same or different substituents selected from R4; and R4 is hydrogen, amino, thioxo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, halogen, oxo, thia, or hydroxy; or pharmaceutically acceptable salts, hydrates or solvates thereof, have been found to exhibit PDE4 inhibiting activity, and may therefore be useful in the treatment of inflammatory diseases and disorders.
Public/Granted literature
- US20150111915A1 BENZODIOXOLE OR BENZODIOXEPINE HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS Public/Granted day:2015-04-23
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