Invention Grant
- Patent Title: Substituted pyridone derivatives as PDE10 inhibitors
- Patent Title (中): 取代的吡啶酮衍生物作为PDE10抑制剂
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Application No.: US14443624Application Date: 2013-11-15
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Publication No.: US09273033B2Publication Date: 2016-03-01
- Inventor: Scott D. Kuduk , Casey C. McComas , Thomas S. Reger
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; John C. Todaro
- International Application: PCT/US2013/070211 WO 20131115
- International Announcement: WO2014/081617 WO 20140530
- Main IPC: C07D403/14
- IPC: C07D403/14 ; A61K31/506 ; C07D401/14 ; C07D471/04
Abstract:
The present invention is directed to substituted pyridinone compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
Public/Granted literature
- US20150291561A1 SUBSTITUTED PYRIDONE DERIVATIVES AS PDE10 INHIBITORS Public/Granted day:2015-10-15
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