Invention Grant
US09272996B2 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
有权
2-酰基氨基丙醇型葡萄糖神经酰胺合成酶抑制剂
- Patent Title: 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
- Patent Title (中): 2-酰基氨基丙醇型葡萄糖神经酰胺合成酶抑制剂
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Application No.: US13595251Application Date: 2012-08-27
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Publication No.: US09272996B2Publication Date: 2016-03-01
- Inventor: Craig Siegel , Cecilia M. Bastos , David J. Harris , Angeles Dios , Edward Lee , Richard Silva , Lisa M. Cuff , Mikaela Levine , Cassandra A. Celatka , Thomas H. Jozefiak , Frederic Vinick , Yibin Xiang , John Kane , Junkai Liao
- Applicant: Craig Siegel , Cecilia M. Bastos , David J. Harris , Angeles Dios , Edward Lee , Richard Silva , Lisa M. Cuff , Mikaela Levine , Cassandra A. Celatka , Thomas H. Jozefiak , Frederic Vinick , Yibin Xiang , John Kane , Junkai Liao
- Applicant Address: US MA Cambridge
- Assignee: Genzyme Corporation
- Current Assignee: Genzyme Corporation
- Current Assignee Address: US MA Cambridge
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Main IPC: A61K31/397
- IPC: A61K31/397 ; A61K31/5377 ; A61K31/44 ; A61K31/325 ; A61K31/42 ; A61K31/40 ; C07D207/12 ; C07D271/12 ; C07D317/60 ; C07D319/18 ; C07D333/16 ; C07D407/12 ; C07D409/04 ; C07D413/04 ; C07D417/12 ; C07C271/12 ; C07D319/20 ; C07D407/06
Abstract:
A compound for use in treating polycystic kidney disease is represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating polycystic kidney disease in a subject in need thereof comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. Methods of treating in polycystic kidney disease in a subject in need thereof respectively comprise administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20120322786A1 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS Public/Granted day:2012-12-20
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