A structure for connecting a wheel house panel with a rear floor of a vehicle, which connects the rear floor forming a rear portion of a bottom of the vehicle with the wheel house panel on which shock absorber mounting brackets attached to both sides of the rear floor and supporting a shock absorber are mounted may include a first member bending between a lower end of an inner side of the wheel house panel and a side of the rear floor, with both ends attached to the wheel house panel and the rear floor, respectively, a second member vertically elongated and attached to an outer side of the wheel house panel and disposed behind the shock absorber mounting brackets, and a third member vertically elongated and attached to the outer side of the wheel house panel and disposed in front of the shock absorber mounting brackets.