Invention Grant
- Patent Title: Osteoinductive nanocomposites
- Patent Title (中): 骨诱导性纳米复合材料
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Application No.: US12994933Application Date: 2009-05-27
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Publication No.: US09272071B2Publication Date: 2016-03-01
- Inventor: Davide Barbieri , Huipin Yuan , Joost Dick De Bruijn
- Applicant: Davide Barbieri , Huipin Yuan , Joost Dick De Bruijn
- Applicant Address: NL Bilthoven
- Assignee: REVISIOS B.V. I.O.
- Current Assignee: REVISIOS B.V. I.O.
- Current Assignee Address: NL Bilthoven
- Agency: Renner, Otto, Boisselle & Sklar, LLP
- Priority: EP08157009 20080527
- International Application: PCT/NL2009/050296 WO 20090527
- International Announcement: WO2009/145630 WO 20091203
- Main IPC: A61L27/46
- IPC: A61L27/46

Abstract:
The present invention relates porous osteoinductive nanocomposites and for the methods to prepare osteoinductive nanocomposites. The osteoinductive composites consist of biocompatible polymers and non-heated (or non-sintered), needle-shaped or plate-like calcium phosphate nanocrystals and the methods comprise the steps of: a. adding phosphate to a calcium solution thereby evoking precipitation of calcium phosphate nanocrystals; b. washing the nanocrystals with water and suspending them in an organic solvent or getting dry calcium phosphate nanocrystals after evaporating organic solvent; c. adding polymers (previously dissolved in an organic solvent) to calcium phosphate nanocrystal suspension, rotational mixing of the components using beads, mixing with porogenic agents, moulding the composite material and evaporating of the organic solvent; or mixing polymers (not dissolved in an organic solvent but raw powder), dry calcium phosphate nanocrystals and porogenic agents with melting intrusion and moulding the composites; d. leaching porogenic agents in water.
Public/Granted literature
- US20110111004A1 OSTEOINDUCTIVE NANOCOMPOSITES Public/Granted day:2011-05-12
Information query
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