Invention Grant
- Patent Title: Agents for the molecular imaging of serine-protease in human pathologies
- Patent Title (中): 人类病理学中丝氨酸蛋白酶分子成像剂
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Application No.: US13990845Application Date: 2011-12-05
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Publication No.: US09272054B2Publication Date: 2016-03-01
- Inventor: Jean-Baptiste Michel , François Rouzet , Dominique Leguludec , Hervé Poras , Marie-Claude Fournie-Zaluski , Bernard Rogues
- Applicant: Jean-Baptiste Michel , François Rouzet , Dominique Leguludec , Hervé Poras , Marie-Claude Fournie-Zaluski , Bernard Rogues
- Applicant Address: FR Paris FR Paris FR Paris FR Paris
- Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM),Pharmaleads,Assistance Publique Hopitaux de Paris,Universite Paris Diderot-Paris 7
- Current Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM),Pharmaleads,Assistance Publique Hopitaux de Paris,Universite Paris Diderot-Paris 7
- Current Assignee Address: FR Paris FR Paris FR Paris FR Paris
- Agency: Whitham Curtis Christofferson & Cook, PC
- Priority: EP10306343 20101203; EP11305405 20110407
- International Application: PCT/EP2011/071774 WO 20111205
- International Announcement: WO2012/072819 WO 20120607
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14 ; A61K49/00 ; A61K49/14 ; A61K51/08
Abstract:
The present invention is directed to the use of an irreversible ligand of a serine protease selected from the group consisting of leukocyte elastase, thrombin, tissue plasminogen activator (t-PA) and plasmin for the molecular imaging of said serine protease and the diagnosis of pathophysiological conditions associated with said serine protease activity.
Public/Granted literature
- US20130243691A1 AGENTS FOR THE MOLECULAR IMAGING OF SERINE-PROTEASE IN HUMAN PATHOLOGIES Public/Granted day:2013-09-19
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