Methods for treating ailments in a patient in need thereof includes the step of directing a therapeutic, non-inhaled dosage to at least one nasal cavity of the patient through a flow regulating device while the patient refrains from inhaling. The dosage includes (a) a saline fluid (b) a gas containing carbon dioxide and (c) at least one additional active component, wherein the therapeutic, non-inhaled dosage is delivered at a flow rate from 1 cc/sec to 20 cc/sec for a duration of 2 to 30 seconds.