Invention Grant
US09272026B2 HLA-A*1101-restricted WT1 peptide and pharmaceutical composition comprising the same 有权
HLA-A * 1101限制性WT1肽和包含其的药物组合物

HLA-A*1101-restricted WT1 peptide and pharmaceutical composition comprising the same
Abstract:
An HLA-A*1101-restricted WT1 peptide, specifically, a peptide comprising an amino acid sequence consisting of 9 contiguous amino acids from a WT1 protein, wherein the peptide has an ability to bind to an HLA-A*1101 molecule, and has an ability to induce a CTL is described. A peptide dimer having an ability to bind to an HLA-A*1101 molecule and having an ability to induce a CTL, in which two peptide monomers each comprising an amino acid sequence consisting of 9 contiguous amino acids from a WT1 protein and comprising at least one cysteine residue are bound to each other through a disulfide bond is also described. Furthermore, a polynucleotide encoding the peptide, a pharmaceutical composition for the treatment and/or prevention of a cancer comprising the same and the like are provided.
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