Invention Grant
US09272026B2 HLA-A*1101-restricted WT1 peptide and pharmaceutical composition comprising the same
有权
HLA-A * 1101限制性WT1肽和包含其的药物组合物
- Patent Title: HLA-A*1101-restricted WT1 peptide and pharmaceutical composition comprising the same
- Patent Title (中): HLA-A * 1101限制性WT1肽和包含其的药物组合物
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Application No.: US14140698Application Date: 2013-12-26
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Publication No.: US09272026B2Publication Date: 2016-03-01
- Inventor: Haruo Sugiyama
- Applicant: International Institute of Cancer Immunology, Inc.
- Applicant Address: JP Osaka
- Assignee: International Institute of Cancer Immunology, Inc.
- Current Assignee: International Institute of Cancer Immunology, Inc.
- Current Assignee Address: JP Osaka
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: JP2006-355356 20061228
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/00 ; A61K39/00 ; C07K14/47 ; G01N33/574

Abstract:
An HLA-A*1101-restricted WT1 peptide, specifically, a peptide comprising an amino acid sequence consisting of 9 contiguous amino acids from a WT1 protein, wherein the peptide has an ability to bind to an HLA-A*1101 molecule, and has an ability to induce a CTL is described. A peptide dimer having an ability to bind to an HLA-A*1101 molecule and having an ability to induce a CTL, in which two peptide monomers each comprising an amino acid sequence consisting of 9 contiguous amino acids from a WT1 protein and comprising at least one cysteine residue are bound to each other through a disulfide bond is also described. Furthermore, a polynucleotide encoding the peptide, a pharmaceutical composition for the treatment and/or prevention of a cancer comprising the same and the like are provided.
Public/Granted literature
- US20140134200A1 HLA-A* 1101-RESTRICTED WT1 PEPTIDE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME Public/Granted day:2014-05-15
Information query
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