Invention Grant
- Patent Title: Oncolytic measles virus
- Patent Title (中): 溶瘤麻疹病毒
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Application No.: US13818053Application Date: 2011-08-19
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Publication No.: US09272008B2Publication Date: 2016-03-01
- Inventor: Ulrich M. Lauer , Michael Bitzer , Johanna Lampe , Martina Zimmermann , Susanne Berchtold , Sebastian Lange , Wolfgang J. Neubert , Sascha Bossow
- Applicant: Ulrich M. Lauer , Michael Bitzer , Johanna Lampe , Martina Zimmermann , Susanne Berchtold , Sebastian Lange , Wolfgang J. Neubert , Sascha Bossow
- Agency: Arnold & Porter LLP
- Agent Todd A. Lorenz
- Priority: EP10008726 20100820
- International Application: PCT/EP2011/004200 WO 20110819
- International Announcement: WO2012/022495 WO 20120223
- Main IPC: C12N7/00
- IPC: C12N7/00 ; A61K39/165 ; A61K39/00 ; A61K35/768 ; C12N9/10 ; C12N9/78 ; A61K31/7088
Abstract:
The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.
Public/Granted literature
- US20130217757A1 Oncolytic Measles Virus Public/Granted day:2013-08-22
Information query
