Invention Grant
- Patent Title: Method of inhibiting nonsense-mediated mRNA decay
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Application No.: US14082346Application Date: 2013-11-18
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Publication No.: US09271998B2Publication Date: 2016-03-01
- Inventor: Tsafi Pe'ery , Michael B. Mathews , Mainul Hoque , Hartmut M. Hanauske-Abel
- Applicant: Rutgers, The State University of New Jersey
- Applicant Address: US NJ New Brunswick
- Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
- Current Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
- Current Assignee Address: US NJ New Brunswick
- Agency: Fox Rothschild LLP
- Main IPC: A61K31/713
- IPC: A61K31/713 ; A61K31/426 ; A61K31/44 ; A61K31/4412 ; A61K31/4418
Abstract:
Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.
Public/Granted literature
- US20140073685A1 METHOD OF INHIBITING NONSENSE-MEDIATED mRNA DECAY Public/Granted day:2014-03-13
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