Invention Grant
- Patent Title: 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
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Application No.: US13883906Application Date: 2011-11-08
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Publication No.: US09271967B2Publication Date: 2016-03-01
- Inventor: José Maria Cid-Núñez , Andrés Avelino Trabanco-Suárez , Juan Antonio Vega Ramiro , Daniel Oehlrich , Gary John Tresadern , Gregor James Macdonald
- Applicant: José Maria Cid-Núñez , Andrés Avelino Trabanco-Suárez , Juan Antonio Vega Ramiro , Daniel Oehlrich , Gary John Tresadern , Gregor James Macdonald
- Applicant Address: US NJ Titusville
- Assignee: Janssen Pharmaceuticals, Inc.
- Current Assignee: Janssen Pharmaceuticals, Inc.
- Current Assignee Address: US NJ Titusville
- Agent Hal B. Woodrow
- Priority: EP10190326 20101108
- International Application: PCT/EP2011/069640 WO 20111108
- International Announcement: WO2012/062750 WO 20120518
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D491/02 ; A61K31/437 ; A61K45/06 ; C07D471/04 ; A61K9/00 ; A61K9/06 ; A61K9/20
![1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors](/abs-image/US/2016/03/01/US09271967B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to novel triazolo[4,3-a]pyridine derivatives of Formula (I) wherein all radicals are as defined in the claims. The compounds according to the invention are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”), which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.
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