Invention Grant
US09271946B2 Use of a RAR antagonist or inverse agonist for the treatment of chemotherapy and/or radiation therapy side effects
有权
使用RAR拮抗剂或反向激动剂治疗化疗和/或放射治疗副作用
- Patent Title: Use of a RAR antagonist or inverse agonist for the treatment of chemotherapy and/or radiation therapy side effects
- Patent Title (中): 使用RAR拮抗剂或反向激动剂治疗化疗和/或放射治疗副作用
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Application No.: US12291994Application Date: 2008-11-13
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Publication No.: US09271946B2Publication Date: 2016-03-01
- Inventor: Roshantha A. Chandraratna , Yang-Dar Yuan
- Applicant: Roshantha A. Chandraratna , Yang-Dar Yuan
- Applicant Address: US CA Laguna Hills
- Assignee: IO Therapeutics, Inc.
- Current Assignee: IO Therapeutics, Inc.
- Current Assignee Address: US CA Laguna Hills
- Agency: K&L Gates, LLP
- Agent Louis Cullman; Michelle Glasky Bergman
- Main IPC: A61K31/38
- IPC: A61K31/38 ; A61K31/015 ; A61K31/167 ; A61K31/192 ; A61K31/202 ; A61K31/353 ; A61K31/382 ; A61K31/44 ; A61K31/4436 ; A61K31/47
Abstract:
A method for treating chemo therapy or radiation therapy side effects in a mammal undergoing chemotherapy and/or radiation therapy, the method comprising a step of administering to the mammal a therapeutically effective amount of a RAR antagonist or RAR inverse agonist which binds to receptors of the RARα, RARβ and RARγ subtypes is disclosed. Such side effects include chemoradiotherapy-induced alopecia, chemoradiotherapy-induced thrombocytopenia, chemoradiotherapy-induced leucopenia and chemoradiotherapy-induced neutropenia.
Public/Granted literature
- US20090176862A1 Methods for treating chemotherapy and radiation therapy side effects Public/Granted day:2009-07-09
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