Message publish/subscribe systems are required to process high message volumes with reduced latency and performance bottlenecks. The end-to-end middleware architecture proposed by the present invention is designed for high-volume, low-latency messaging by, among other things, reducing intermediary hops with neighbor-based routing, introducing efficient native-to-external and external-to-native protocol conversions, monitoring system performance, including latency, in real time, employing topic-based and channel-based message communications, and dynamically optimizing system interconnect configurations and message transmission protocols.