An image sensor structure is provided. The image sensor structure includes a substrate including a central area and a peripheral area, a sensing area including a plurality of pixels located at the central area of the substrate, a plurality of bond pads disposed at the peripheral area of the substrate, and an array of protrusions disposed between the bond pads and the sensing area and surrounding the sensing area, wherein a largest distance between any two points of the protrusion under a top view is getting smaller from the peripheral area to the central area.