Provided is a drug dispensing box and cartridge having a mutually coupled structure. The cartridge disposed on each of floors of a drug dispensing apparatus and connected to each of a plurality of drug dispensing boxes includes a cartridge housing comprising a lower housing supporting the drug dispensing box and a rear housing restricting entry of the drug dispensing box by a predetermined distance, a rail disposed along an entry path of the drug dispensing box on the lower housing; and a first data transmitting/receiving terminal connected to the drug dispensing box to transmit/receive data. A rail for guiding the drug dispensing box when the drug dispensing box and the cartridge are connected to each other may be provided to connect the drug dispensing box to the cartridge at a regular position.