Methods and a computer program product for deriving a super-resolution image of a physical object by fusing cameras of multiple resolutions (spatial, temporal, or spectral), the super-resolution image characterized by a resolution exceeding a “camera imaging resolution” associated with each of a sequence of lower-resolution images of the physical object. The sequence of images of the physical object is obtained at a plurality of relative displacements with respect to the object by a hybrid camera system comprising at least two imaging systems. The imaging systems are characterized by respective temporal and spatial resolution and by spectral sensitivity, and may be distinct from one another in one or more of the foregoing dimensions. The imaging systems are either fixed, or subject to know motion, relative to each other. Image sequences derived by each imaging system are coregistered and deconvolved to solve for a resultant sequence of images.