Invention Grant
- Patent Title: Modulators of alpha-synuclein toxicity
-
Application No.: US13931004Application Date: 2013-06-28
-
Publication No.: US09249444B2Publication Date: 2016-02-02
- Inventor: Susan L. Lindquist , Aaron D. Gitler
- Applicant: Whitehead Institute for Biomedical Research
- Applicant Address: US MA Cambridge
- Assignee: Whitehead Institute for Biomedical Research
- Current Assignee: Whitehead Institute for Biomedical Research
- Current Assignee Address: US MA Cambridge
- Agency: Fish & Richardson P.C.
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/85 ; C12Q1/02 ; C12Q1/68 ; G01N33/68
Abstract:
Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
Public/Granted literature
- US20140051091A1 MODULATORS OF ALPHA-SYNUCLEIN TOXICITY Public/Granted day:2014-02-20
Information query
