Invention Grant
- Patent Title: Oligonucleotide compounds comprising non-nucleotide overhangs
- Patent Title (中): 包含非核苷酸突出端的寡核苷酸化合物
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Application No.: US14485828Application Date: 2014-09-15
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Publication No.: US09249414B2Publication Date: 2016-02-02
- Inventor: Sharon Avkin-Nachum , Elena Feinstein
- Applicant: QUARK PHARMACEUTICALS, INC.
- Applicant Address: US CA Fremont
- Assignee: QUARK PHARMACEUTICALS, INC.
- Current Assignee: QUARK PHARMACEUTICALS, INC.
- Current Assignee Address: US CA Fremont
- Agency: JMB Davis Ben-David
- Main IPC: A61K31/713
- IPC: A61K31/713 ; C12N15/113
Abstract:
The invention relates to siRNA compounds comprising one non-nucleotide moiety covalently attached to at least one of the sense or antisense strands to down-regulate the expression of human genes. The invention also relates to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier and to methods of treating and/or preventing the incidence or severity of various diseases or conditions associated with the target genes and/or symptoms associated with such diseases or conditions.
Public/Granted literature
- US20150159154A1 OLIGONUCLEOTIDE COMPOUNDS COMPRISING NON-NUCLEOTIDE OVERHANGS Public/Granted day:2015-06-11
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