Invention Grant
- Patent Title: Anti-Axl antibodies and uses thereof
- Patent Title (中): 抗Axl抗体及其用途
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Application No.: US14127415Application Date: 2012-06-22
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Publication No.: US09249228B2Publication Date: 2016-02-02
- Inventor: Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
- Applicant: Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
- Applicant Address: FR Montpellier Cedex FR Montpellier Cedex FR Paris FR Montpellier Cedex
- Assignee: ORIBASE PHARMA,Institut Regional du Cancer de Montpellier-Val d' Aurelle,INSERM (Institut National de la Sante et de la Recherche Medicale),UNIVERSITE DE MONTPELLIER 1
- Current Assignee: ORIBASE PHARMA,Institut Regional du Cancer de Montpellier-Val d' Aurelle,INSERM (Institut National de la Sante et de la Recherche Medicale),UNIVERSITE DE MONTPELLIER 1
- Current Assignee Address: FR Montpellier Cedex FR Montpellier Cedex FR Paris FR Montpellier Cedex
- Agency: McAndrews, Held & Malloy Ltd.
- Priority: EP11305793 20110622
- International Application: PCT/EP2012/062114 WO 20120622
- International Announcement: WO2012/175691 WO 20121227
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/30 ; A61K39/395 ; C07K16/40 ; G01N33/574 ; A61K39/00
Abstract:
The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9, SEQ ID NO: 10 and SEQ ID NO: 11.
Public/Granted literature
- US20140302041A1 ANTI-AXL ANTIBODIES AND USES THEREOF Public/Granted day:2014-10-09
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