Invention Grant
- Patent Title: Tau imaging probe
- Patent Title (中): Tau成像探头
-
Application No.: US13881872Application Date: 2011-10-28
-
Publication No.: US09249101B2Publication Date: 2016-02-02
- Inventor: Yukitsuka Kudo , Shozo Furumoto , Nobuyuki Okamura
- Applicant: Yukitsuka Kudo , Shozo Furumoto , Nobuyuki Okamura
- Applicant Address: JP Sendai-shi Miyagi
- Assignee: CLINO LTD.
- Current Assignee: CLINO LTD.
- Current Assignee Address: JP Sendai-shi Miyagi
- Agency: Nixon Peabody LLP
- Agent Jeffrey L. Costellia
- Priority: JP2010-243532 20101029; JP2011-106569 20110511
- International Application: PCT/JP2011/074930 WO 20111028
- International Announcement: WO2012/057312 WO 20120503
- Main IPC: A61K31/535
- IPC: A61K31/535 ; C07D215/12 ; A61K9/00 ; A61K9/08 ; A61K51/04 ; C07D215/20 ; C07D215/233 ; C07D215/26 ; C07D215/38 ; C07D215/40 ; C07D401/04 ; C07D405/12 ; C07D405/14 ; C07D498/04 ; C07D215/14 ; G01N33/68

Abstract:
An object of the present invention is to provide a probe for imaging a β-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity.According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.
Public/Granted literature
- US20130324523A1 TAU IMAGING PROBE Public/Granted day:2013-12-05
Information query