For safe storage and simple and safe administration of tablets T by a user, a cartridge 900 is provided that can be inserted into a medicament dispenser 1 for solid medicament portions T and that is designed with a reservoir for receiving the medicament portions T, and a medicament dispenser 1 containing this cartridge 900 is also provided. According to the invention, the cartridge 900 comprises a transport safety mechanism for preventing movement of the medicament portions T during storage and transport of the cartridge 900 . This transport safety mechanism is in particular a tolerance compensation plug 970 that sits with a frictional fit in the reservoir and that is movable in the axial direction. The cartridge 900 also contains a tablet rider 960 which is movable in the axial direction in the reservoir and which engages through at least one axial slit in the cartridge 900 and with which a force acting in the axial direction is transferred to the medicament portions (T) in the cartridge, thus serving to hold down a column-shaped arrangement of medicament portions (T).