The present invention relates to an adjustable large-sized advertisement curtain wind-resistant module, which includes a base, the slidable board, a coupler, a transmission device, and a transmission rod. The base has a screw rod. The slidable board has a surface slidably mounted to the base and coupled with the screw rod and an opposite surface to which the coupler is mounted for coupling with the frame. The transmission device is arranged in the base and coupled to the screw rod. The transmission rod drives the transmission device and the transmission device in turn drives the screw rod, so that the screw rod may drive the slidable board to do linear displacement on the base. The linear displacement of the slidable board in opposite directions carries the frame to be moved in unison therewith to achieve adjustment of distance between two frames for stretching flat an advertisement curtain between the frames.