Provided are an image pickup device and a camera system that are capable of detecting an extremely small signal from a pixel or one photon signal with low noise and high precision at high speed, and are capable of performing various kinds of high-performance shooting by increasing a frame rate with use of this. Each sense circuit includes a comparator configured to compare an output signal from a pixel with a reference signal, and when signal detection is performed, a charge allowing a first pixel signal output from a selected pixel to be cancelled out is held in one or both of input sections of the comparator, an independent offset bias for each comparator is applied to one of the input sections of the comparator to cancel out an offset of the comparator, and a digital decision on intensity of light incident on the pixel is performed by comparing a reference signal changing in steps with a second pixel signal output from the selected pixel.