Invention Grant
US09096869B2 Recombinant nonpathogenic MDV vector providing multivalent immunity
有权
重组非致病性MDV载体提供多价免疫
- Patent Title: Recombinant nonpathogenic MDV vector providing multivalent immunity
- Patent Title (中): 重组非致病性MDV载体提供多价免疫
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Application No.: US14351739Application Date: 2012-10-19
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Publication No.: US09096869B2Publication Date: 2015-08-04
- Inventor: Paulus Jacobus Antonius Sondermeijer , Iwan Verstegen
- Applicant: Intervet Inc.
- Applicant Address: US NJ Summit
- Assignee: Intervet, Inc.
- Current Assignee: Intervet, Inc.
- Current Assignee Address: US NJ Summit
- Priority: EP11186237 20111021
- International Application: PCT/EP2012/070727 WO 20121019
- International Announcement: WO2013/057235 WO 20130425
- Main IPC: A61K39/17
- IPC: A61K39/17 ; A61K39/255 ; C12N7/01 ; C12N15/869 ; C12N15/86 ; A61K39/12 ; C07K14/005 ; A61K39/00

Abstract:
The present invention relates to the field of veterinary vaccines, in particular to that of vector vaccines for poultry based on recombinant nonpathogenic Marek's disease virus (npMDV). The recombinant npMDV of the invention expresses stably and effectively two heterologous genes each originating from a different micro-organism: the fusion protein gene from Newcastle disease virus, and the viral protein 2 gene from infectious bursal disease virus. A vaccine based on this recombinant npMDV can be used to induce in poultry a protective immune response not only against Marek's disease, but also against Newcastle disease and Infectious bursal disease. The invention also relates to methods and uses involving the recombinant npMDV, expression cassette, infected host cells, and vaccines.
Public/Granted literature
- US20140294893A1 RECOMBINANT NONPATHOGENIC MDV VECTOR PROVIDING MULTIVALENT IMMUNITY Public/Granted day:2014-10-02
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