Invention Grant
US09095536B2 Aβ immunogenic peptide carrier conjugates and methods of producing same
有权
A&bgr 免疫原性肽载体缀合物及其生产方法
- Patent Title: Aβ immunogenic peptide carrier conjugates and methods of producing same
- Patent Title (中): A&bgr 免疫原性肽载体缀合物及其生产方法
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Application No.: US11841919Application Date: 2007-08-20
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Publication No.: US09095536B2Publication Date: 2015-08-04
- Inventor: Rasappa G. Arumugham , A. Krishna Prasad , Michael Hagen
- Applicant: Rasappa G. Arumugham , A. Krishna Prasad , Michael Hagen
- Applicant Address: IE County Cork US NY New York
- Assignee: Janssen Sciences Ireland UC,Wyeth LLC
- Current Assignee: Janssen Sciences Ireland UC,Wyeth LLC
- Current Assignee Address: IE County Cork US NY New York
- Agency: Alston & Bird LLP
- Main IPC: A61K38/04
- IPC: A61K38/04 ; C07K7/06 ; C07K17/00 ; G01N33/532 ; A61K39/00 ; A61K47/48

Abstract:
The present invention is directed to methods of producing conjugates of Aβ peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.
Public/Granted literature
- US20080145373A1 A-BETA IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME Public/Granted day:2008-06-19
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