Systems and methods of determining motion vectors, such as for video encoding, are disclosed. In one example, motion vectors are determined for a current frame, using sampled pixel information from a reference frame. Sampled pixel information is obtained using a sampling pattern. The sampling pattern, in one example, includes subsampling pixels at different rates for horizontal and vertical directions. The subsampling rate can differ, based on an amount of motion represented by a matching block (e.g., the farther a match is found away from an origin of the block, the more subsampling can be done). In another example, a full pixel resolution is maintained proximal an original location of the block; as distance increases in one or more directions, subsampling can begin and/or increase. Sampled pixels can be stored. Interpolation of the sampled pixels can be performed and the sampled and resulting interpolated pixels can be used for comparison.